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The Truvia® stevia leaf extract safety evaluation program included metabolism and pharmacokinetic studies, general and multi-generational safety studies, intake studies and human studies. Cargill sponsored the studies to affirm earlier safety findings for purified steviol glycosides, and to confirm that Truvia® stevia leaf extract is broken down by the body in the same way as stevioside, which has been studied extensively. Rebaudioside A - the main component of Truvia® stevia leaf extract - is nearly identical in chemical structure to stevioside.
Study |
Top-line Findings |
Implications |
|---|---|---|
| Metabolism and pharmacokinetic studies |
Metabolism of rebaudioside A is similar to that of stevioside |
Safety data from stevioside studies can be applied to Truvia® stevia leaf extract The safety of Truvia® stevia leaf extract is supported by a large database of scientific research |
| General safety |
No negative effects on general health associated with doses equivalent to a 150-lb person drinking more than 2,000 8-ounce servings of a Truvia® stevia leaf extract-sweetened beverage No treatment-related effects on any organ, including kidneys and male reproductive organs |
Supports safety of high-purity steviol glycoside ingredients, including Truvia® stevia leaf extract Refutes outdated studies suggesting adverse effects of stevia or stevioside on male reproductive organs (1985, 1999) or on kidney function (1988, 1994, 1997) Truvia® stevia leaf extract does not affect general health or organ function |
| Multi-generational/ reproductive toxicology |
Daily consumption equivalent to a 150-lb person drinking nearly 1,000 8-oz servings of a Truvia® stevia leaf extract-sweetened beverage had no negative effects on general health, reproduction, growth or development of adults or their offspring |
Refutes studies (1968, 1985, 1998, 1999) suggesting potential adverse effects on male or female fertility, or health of offspring Truvia® stevia leaf extract does not affect reproductive health or health of offspring |
| Chronic blood pressure study |
Daily consumption of 1,000 mg Truvia® stevia leaf extract - equivalent to drinking more than eight 8-oz servings of a Truvia® stevia leaf extract-sweetened beverage every day - for 4 weeks had no significant blood pressure effects in healthy subjects with normal or low-normal blood pressure |
Addresses questions raised by two Taiwanese studies (2000 and 2003) suggesting that stevioside (purity unknown) lowered blood pressure in people with essential hypertension Truvia® stevia leaf extract does not affect blood pressure |
| Chronic blood sugar study |
Daily consumption of 1,000 mg of Truvia® stevia leaf extract - equivalent to drinking more than eight 8-ounce servings of a Truvia® stevia leaf extract-sweetened beverage every day - for 16 weeks did not affect blood sugar control and was well-tolerated in people with type 2 diabetes |
Addresses questions raised by a single-dose study (2004) suggesting that stevioside reduced levels of blood sugar after meals in people with type 2 diabetes Truvia® stevia leaf extract does not affect blood sugar control in people with type 2 diabetes |
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In safety studies, daily consumption of Truvia® stevia leaf extract equivalent to a 150-lb person drinking between 1,000 and 2,000 8-ounce servings of Truvia® stevia leaf extract-sweetened beverage had no negative effects on the general health, reproduction, growth or development of adults or their offspring. In clinical studies, daily consumption of 1,000 mg Truvia® stevia leaf extract - equivalent to consuming 29 packets of sweetener or drinking approximately eight 8-ounce servings of a Truvia® Truvia® stevia leaf extract-sweetened beverage every day for 4 or 16 weeks - had no effect on blood pressure in healthy subjects with normal or low-normal blood pressure; or on blood sugar control in subjects with type 2 diabetes. |
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